The Noyes Lab started at the NYU School of Medicine in the summer of 2015. We are interested in how proteins interact with their targets from structural, computational and cell biology perspectives. As such, our primary goals involve developing new tools to sample these interactions as comprehensively as possible. Our research could be classified as Systems or Synthetic Biology but we hope not to lose sight of the Cell Biology that this is all predicated upon.
We are currently in a big state of transition as we have recently developed a technique to reprogram transcription factors. This has opened up several avenues of research and is a very exciting time.
As Such, we are looking for people from the techncian to postdoctoral level. Please feel free to contact me directly.
**a special thanks to April Mueller for making the awesome Noyes Lab logo above!
Here are some potential rotation projects:
The great majority of mutations associated with disease are non-coding sequences suggesting that misregulation of genes is a common mechanism of disease. To address these problems we are developing artificial regulators that could correct the misregulation. Several projects would focus on the development of these artificial regulators with novel effector domains fused to Cas9, zinc fingers, or other targeting domains. In addition, computational approaches need to be developed to best connect these disease associated SNPs with the gene's they regulate.
PDZ domains interact with the C-terminus of their protein binding partners. The domains in prokaryotes have been largely overlooked even though there are more PDZs in the human microbiome than there are in the human genome! We would like to characterize the interacting partners of these domains to predict what regulatory pathways they are associated with and how that impacts the homeostasis of the microbiome.
Engineering PDZ domains with novel peptide specificity to create targeted proteases for the degradation of proteins associated with cancer.
Zinc fingers are the most common DNA-binding domain in metazoans and we loosely understand how they interact with DNA, but how do they interact with each other? Investigate how adjacent domains influence the target preference of one another for understanding transcription factors and domain design.
many, many more possibilities!
Bio, Marcus Noyes PhD
Dr Evil in his new office...
Dr. Marcus Noyes joined the NYU Institute for Systems Genetic and the Department of Biochemistry and Molecular Pharmacology in July of 2015. Dr. Noyes received his PhD from the University of Massachusetts Medical School where he developed tools for the high-throughput characterization of protein-DNA interactions. He was next recruited as an independent Lewis-Sigler Fellow at Princeton University where he ran a small lab for 5 years before accepting his current position at NYU. His research rests on the edge of Systems and Synthetic Biology, focusing on the development of tools that allow us to understand the binding potential of common protein domains important for biological functions. Using comprehensive, synthetic screens of these protein domains, the goal of his research is to understand the complete functional capacity of a protein and not be limited by the sometimes small set of functions that have evolved. This approach has the added benefit of producing new proteins with novel functions that can be applied to therapeutic applications such as artificial regulation, protein inhibition and precise genome editing.